安徽医科大学第一附属医院泌尿外科;
长链非编码RNA(LncRNA)是一种长度超过200个左右核苷酸的非编码RNA,曾被认为是DNA的"转录噪音",但现已证实其广泛参与基因表达调控,并在细胞增殖、分化、凋亡以及肿瘤的发生、进展过程中起关键作用。目前已有系列lncRNA被证实参与调控前列腺癌进展,包括癌细胞从激素敏感性到去势抵抗性的转化过程等。雄激素受体(AR)是目前临床实践和科学研究共同证实的在前列腺癌发生和进展过程中最为关键作用的调控因子,而当前研究亦证实lncRNA可通过影响AR通路,继而影响前列腺癌的进展和耐药。故此,厘清AR和lncRNA之间的互作关联有助于了解前列腺癌发病或进展的生物学机制,并为前列腺癌的治疗提供一定思路。
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[1] Parkin DM,Bray F,Ferlay J,et al.Global cancer statistics,2002.CA Cancer J Clin,2005,55(2):74-108 .
[2] 丁涛,车文骏,陈同珏.前列腺癌组织中性激素受体表达的分析.中华男科学杂志,2006,12(1):50-52.
[3] 马建国,李文平,蒋玉清.雄激素受体突变在前列腺癌进展中的作用.中华男科学杂志,2011,17(7):649-654.
[4] Sudhanshu S,Zhang X,Niknafs YS,et al.Identification and validation of PCAT14 as prognostic biomarker in prostate cancer.Neoplasia,2016,18(8):489-499.
[5] Crea F,Watahiki A,Quagliata L,et al.Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer.Oncotarget,2014,5(3):764-774.
[6] Malik R,Patel L,Prensner JR,et al.The lncRNA PCAT29 inhibits oncogenic phenotypes in prostate cancer.Mol Cancer Res,2014,12(8):1081-1087.
[7] Sakurai K,Reon BJ,Anaya J,et al.The lncRNA DRAIC/PCAT29 locus constitutes a tumor-suppressive nexus.Mol Cancer Res,2015,13(5):828-838.
[8] Wan X,Huang W,Yang S,et al.Identification of androgen-responsive lncRNAs as diagnostic and prognostic markers for prostate cancer.Oncotarget,2016,7(37):60503-60518.
[9] Sheng L,Ye L,Zhang D,et al.New insights into the long non-coding RNA SRA:Physiological functions and mechanisms of action.Front Med (Lausanne),2018,5:244.
[10] Foulds CE,Tsimelzon A,Long W,et al.Research resource:Expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene.Mol Endocrinol,2010,24(5):1090-1105.
[11] Kurisu T,Tanaka T,Ishii J,et al.Expression and function of human steroid receptor RNA activator in prostate cancer cells:Role of endogenous hSRA protein in androgen receptor-mediated transcription.Prostate Cancer Prostatic Dis,2006,9(2):173-178.
[12] Kawashima H,Takano H,Sugita S,et al.A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene:Expression in prostate cancer cells and enhancement of androgen receptor activity.Biochem J,2003,369(Pt 1):163-171.
[13] Agoulnik IU,Weigel NL.Coactivator selective regulation of androgen receptor activity.Steroids,2009,74(8):669-674.
[14] Sun T,Du SY,Armenia J,et al.Expression of lncRNA MIR222HG co-transcribed from the miR-221/222 gene promoter facilitates the development of castration-resistant prostate cancer.Oncogenesis,2018,7(3):30.
[15] Rinn JL,Kertesz M,Wang JK,et al.Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell,2007,129(7):1311-1323.
[16] Zhang A,Zhao JC,Kim J,et al.LncRNA HOTAIR enhances the androgen-receptor-mediated transcriptional program and drives castration-resistant prostate cancer.Cell Rep,2015,13(1):209-221.
[17] Lemos AE,Ferreira LB,Batoreu NM,et al.PCA3 long noncoding RNA modulates the expression of key cancer-related genes in LNCaP prostate cancer cells.Tumour Biol,2016,37(8):11339-11348.
[18] Ferreira LB,Palumbo A,de Mello KDd,et al.PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling.BMC Cancer,2012,12:507.
[19] Sung YY,Cheung E.Androgen receptor co-regulatory networks in castration-resistant prostate cancer.Endocr Relat Cancer,2014,21(1):R1-R11.
[20] Auprich M,Haese A,Walz J,et al.External validation of urinary PCA3-based nomograms to individually predict prostate biopsy outcome.Eur Urol,2010,58(5):727-732.
[21] Srikantan V,Zou Z,Petrovics G,et al.PCGEM1,a prostate-specific gene,is overexpressed in prostate cancer.Proc Natl Acad Sci USA,2000,97(22):12216-12221.
[22] Li CH,Chen Y.Targeting long non-coding RNAs in cancers:Progress and prospects.Int J Biochem Cell Biol,2013,45(8):1895-1910.
[23] Yang L,Lin C,Jin C,et al.lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs.Nature,2013,500(7464):598-602.
[24] Prensner JR,Sahu A,Iyer MK,et al.The IncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer.Oncotarget,2014,5(6):1434-1438.
[25] Takayama K,Horie-Inoue K,Katayama S,et al.Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer.EMBO J,2013,32(12):1665-1680.
[26] Cui Z,Ren S,Lu J,et al.The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor.Urol Oncol,2013,31(7):1117-1123.
[27] Yang Q,Cui ZL,Wang Q,et al.PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells.Asian J Androl,2017,19(4):453-457.
[28] Weiss M,Plass C,Gerhauser C.Role of lncRNAs in prostate cancer development and progression.Biol Chem,2014,395(11):1275-1290.
[29] Fang Z,Xu C,Li Y,et al.A feed-forward regulatory loop between androgen receptor and PlncRNA-1 promotes prostate cancer progression.Cancer Lett,2016,374(1):62-74.
[30] 杨雨叶,朱月春.长链非编码RNA GAS5在肿瘤中的作用及其机制.生命的化学,2017,(6).
[31] Song W,Wang K,Zhang RJ,et al.Long noncoding RNA GAS5 can predict metastasis and poor prognosis:A meta-analysis.Minerva Med,2016,107(1):70-76.
[32] Mourtada-Maarabouni M,Pickard MR,Hedge VL,et al.GAS5,a non-protein-coding RNA,controls apoptosis and is downregulated in breast cancer.Oncogene,2009,28(2):195-208.
[33] Pickard MR,Mourtada-Maarabouni M,Williams GT.Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines.Biochim Biophys Acta,2013,1832(10):1613-1623.
[34] Zhang Y,Su X,Kong Z,et al.An androgen reduced transcript of LncRNA GAS5 promoted prostate cancer proliferation.PLoS One,2017,12(8):e0182305.
[35] Kino T,Hurt DE,Ichijo T,et al.Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor.Sci Signal,2010,3(107):ra8.
[36] Zhang Y,Pitchiaya S,Cieslik M,et al.Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression.Nat Genet,2018,50(6):814-824.
[37] Jia J,Li F,Tang XS,et al.Long noncoding RNA DANCR promotes invasion of prostate cancer through epigenetically silencing expression of TIMP2/3.Oncotarget,2016,7(25):37868-37881.
[38] Misawa A,Takayama K,Urano T,et al.Androgen-induced long noncoding RNA (lncRNA) SOCS2-AS1 promotes cell growth and inhibits apoptosis in prostate cancer cells.J Biol Chem,2016,291(34):17861-17880.
[39] Misawa A,Takayama KI,Fujimura T,et al.Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells.Cancer Sci,2017,108(3):373-379.
[40] 刘磊.长链非编码RNA linc00844在前列腺癌中作用的研究(博士论文).济南:山东大学,2017.
[41] Lingadahalli S,Jadhao S,Sung YY,et al.Novel lncRNA LINC00844 regulates prostate cancer cell migration and invasion through AR signaling.Mol Cancer Res,2018,16(12):1865-1878.
[42] 吴品庚,张宇曦.长链非编码RNA在前列腺癌中的研究进展.中华男科学杂志,2018,24(8):735-739.
基本信息:
DOI:10.13263/j.cnki.nja.2019.08.012
中图分类号:R737.25
引用信息:
[1]王梦,应杰,张蒙等.前列腺癌中与雄激素受体功能相关的长链非编码RNA研究进展[J].中华男科学杂志,2019,25(08):739-743.DOI:10.13263/j.cnki.nja.2019.08.012.
基金信息: